IGF1 and acromegaly: A recent meta-analysis by Bolfi et al., however, demonstrated that upon control of disease (defined by normalization of IGF-1 level with varying cut-offs based on the study), the cause of death becomes similar to the general population, This analysis showed that the increased cancer incidence was for cancers not typically related to acromegaly, but instead those associated with environmental and genetic factors, as well as aging (31).