ACE2 and diabetes mellitus: Treatment with GLP1RA also increased the expression and the activity of ACE2 in organs like lungs (20, 72), heart (73, 74), and liver (75), restoring the ACE/ACE2 balance, which is impaired in kidney disease (76), diabetes mellitus (20), and cardiac fibrosis (73); moreover, it has been reported that GLP-1RA down-regulated AT1 and up-regulated AT2 in cardiomyocytes, glomerular capillaries and proximal tubules of the renal cortex in rats (73, 74, 77), resulting in a protective effect against ANG II-induced cardiac and kidney fibrosis (73, 74, 77).