More recently, a study of 95 isolated cases with various myoclonic epilepsies showed a higher-than-average proportion of ultra-rare missense ADGRV1 variants: five variants were identified in two patients with Lennox–Gastaut syndrome from a cohort of 46 patients with developmental or epileptic encephalopathies and in two patients from a group of eight with unclassified epilepsies, as well as in two JME patients from a cohort of 41 with GGE (Figure 2) (18). Here, ADGRV1 is linked to juvenile myoclonic epilepsy.