The case of FIG4 gene is an illustrative example; variants in this gene can cause very different AR disorders: (i) Charcot–Marie–Tooth 4J (CMT4J), a peripheral neuropathy (30), (ii) Yunis–Varón syndrome (YVS), in which neurodegeneration and brain malformations are associated with cleidocranial dysplasia, digital anomalies, and early death (31), and (iii) temporo-occipital polymicrogyria with seizures and psychiatric features (32). Here, FIG4 is linked to peripheral neuropathy.