ADGRV1 and Usher syndrome: Loss of function variants in ADGRV1 gene encoding the adhesion G protein-coupled receptor V1 caused the rare autosomal recessive form IIC of Usher syndrome (15), while the Frings mouse, carrying the homozygous c.6835delG (p.Val2250*) variant in Mass1 (the mouse orthologous gene of ADGRV1), displayed generalized auditory-induced seizures (16).