Bioinformatics analysis revealed that Fos is an important link between hypertension and IS, which provides a new perspective of hypertension and its participation in the development and prognosis of cerebral stroke (For simplification purposes, throughout this paper, Fos denotes gene names in rats and cells, FOS denotes gene names in humans, and c-Fos denotes proteins in rats and cells). This evidence concerns the gene FOS and hypertensive disorder.