Gozubatik-Celik et al. (23) demonstrated the presence of neuronal autoantibodies in ca. 14% patients with focal epilepsy of unknown cause (Abs against VGKC-complex, VGCC, GAD, LGI1, CASPR2, NMDA, AMPA, and GABAB receptors), and a similar frequency (up to 20%) for epilepsy with unknown origin was reported by other authors (18, 20, 24). This evidence concerns the gene LGI1 and focal epilepsy.