Approximately 25% of patients with type 2 diabetes (T2D) taking insulin for >5 years have severe hypoglycemic episodes, which is the same as the rate of severe hypoglycemic episodes in adults with type 1 diabetes diagnosed within 5 years (UK Hypoglycaemia Study Group, 2007; Heller et al., 2020). This evidence concerns the gene INS and type 2 diabetes mellitus.