From the regression analysis results shown in Supplementary 3, Supplementary Tables S2–S4, SHBG was a significant independent risk factor for anxiety-like behaviors in infertile women with PCOS, with an odds ratio of 0.979, and LH/FSH was a significant independent risk factor for depression-like behaviors in fertile women with PCOS with an odds ratio of 0.754. The gene discussed is PLOD1; the disease is depressive disorder.