FCF1 and type 1 diabetes mellitus: Further studies revealed a 3- to 4-fold increase of 3-nitrotyrosine levels on BK-α protein in freshly isolated aortas from STZ-induced T1DM rats compared to non-diabetic controls, suggesting that ONOO−-induced modification of BK-α may be mediated through protein tyrosine nitration rather than protein oxidation (Lu et al., 2010).