The effects of DM on myocardial ischemia/reperfusion injury can be reproduced by infusion of 2μM Ang II or 0.1μM membrane impermeable BK channel inhibitor, IBTX, but attenuated by the BK channel activator, NS-1619 (Lu et al., 2016). This evidence concerns the gene KCNMA1 and myocardial ischemia.