Most importantly, the pathological roles of Ang II signaling are supported by clinical outcomes showing that treatment with AT1R blockers and ACE inhibitors reduced cardiovascular complications and cardiovascular death in patients with DM by 25–30% (Niklason et al., 2004; Abuissa et al., 2005; Cheng et al., 2014; Lv et al., 2018). This evidence concerns the gene AGT and diabetes mellitus.