KCNMA1 and metabolic syndrome: In most case, the protein expressions of BK channels are downregulated in coronary arteries (Burnham et al., 2006; Dong et al., 2008; Lu et al., 2008, 2017a; Zhang et al., 2010a; Rueda et al., 2013; Nystoriak et al., 2014; Li et al., 2017), but it was reportedly increased, despite impaired BK channel function in the coronary arteries of Ossabaw miniature swine with metabolic syndrome (Borbouse et al., 2009).