NFE2L2 and Hyperglycemia: In db/db and HFD-induced diabetic mice 6months after the development of hyperglycemia, BK channel activity and BK channel-mediated vasodilation in coronary arteries are impaired, accompanied by a remarkable reduction in Nrf2 and its associated antioxidant enzymes (Li et al., 2017; Lu et al., 2017a).