Abnormal vascular BK channel function was also found in other diabetic animal models, including streptozotocin (STZ)-induced T1DM rodents, db/db T2DM mice, high fat diet (HFD)-induced obesity/diabetic mice and swine (Dimitropoulou et al., 2002; Pietryga et al., 2005; Burnham et al., 2006; McGahon et al., 2007; Yang et al., 2007; Dong et al., 2008; Lu et al., 2008, 2010, 2012, 2016, 2017a; Borbouse et al., 2009; Navedo et al., 2010; Zhang et al., 2010a; Mori et al., 2011; Nystoriak et al., 2014; Yi et al., 2014). Here, KCNMA1 is linked to obesity due to melanocortin 4 receptor deficiency.