Infusion with Ang II (0.05μg/kg) results in markedly enhanced AT1R protein translocation to the low buoyant density fractions of aortas after 1h (83.4% of total membrane AT1R in STZ-induced T1DM rats vs. 28.5% in controls), suggesting enhanced AT1R translocation into caveolae-rich lipid rafts upon agonist activation in diabetic vessels, consistent with previous report in cultured vascular SMCs (Ishizaka et al., 1998). Here, AGT is linked to type 1 diabetes mellitus.