IL4 and airway hyperresponsiveness: The allergic form is an adaptive T helper 2-driven disease characterized by elevated levels of interleukin (IL)-5, interleukin-4 (IL-4), and IL-13, associated with enhanced levels of circulating and lung eosinophils, elevated serum IgE, mucus hypersecretion and airway hyperresponsiveness (Holgate and Polosa, 2008; Chiba et al., 2009; Pelaia et al., 2015).