Among muscular dystrophies, LGMD and Emery-Dreifuss (EDMD) dystrophies are examples of diseases whose majority of the genes was expressed in native and/or MyoD USCs like DES and TTN (Titin) causing LGMD, SYNE1 (Spectrin repeat-containing nuclear envelope protein) involved in the EDMD, DYSF (Dysferlin) associated with LGMD2B and Miyoshi myopathy (Supplementary Table 4). The gene discussed is SYNE1; the disease is limb-girdle muscular dystrophy.