It is noteworthy that also the deficient stimulation of other PRRs, such as NOD2, leads to a higher risk of IBD-CRC: in particular, NOD2−/− mice, treated with AOM to induce IBD-CRC, presented an increase in the number and size of tumors (Couturier-Maillard et al., 2013). The gene discussed is NOD2; the disease is inflammatory bowel disease.