Interestingly, the expression of TLR4 is strongly upregulated in colonic tissues of BALB/c mice treated with azoxymethane/dextran sodium sulphate (AOM/DSS) to induce IBD-CRC, and blocking TLR4 signaling slows the development of the tumor (Pastille et al., 2021). This evidence concerns the gene TLR4 and inflammatory bowel disease.