The epithelial tumor tissue of IBD-CRC patients presents a lower frequency of somatic adenomatous polyposis coli (APC) and Kirsten rat sarcoma virus (KRAS) mutations, while tumor protein P53 (TP53) mutations and Myc proto-oncogene protein (MYC) amplifications are detected earlier during tumor progression in comparison to sCRC (Yaeger et al., 2016; Du et al., 2017; Chatila et al., 2020). The gene discussed is TP53; the disease is inflammatory bowel disease.