NFKB1 and colorectal carcinoma: This effect is also enhanced by the anti-apoptotic role of NF-κB; in fact in a IBD-CRC mouse model, it was demonstrated that NF-κB suppresses apoptosis through the induction of the anti-apoptotic protein B-cell lymphoma-extra large (Bcl-xL) (Greten et al., 2004).