Li et al. found that APBPC-3 could inhibit the proliferation of DU145 prostate cancer cells, and underlying mechanism might be related to the downregulating of the PI3K/Akt signaling proteins PI3K, Akt-1 and Bcl-2, as well the upregulation of PTEN, P53, caspase-3 and Bax (Li S. F. et al., 2021). Here, AKT1 is linked to Familial prostate cancer.