Meanwhile, we also noted that the HCT116/CXCL14 cells were characterized with downregulation of epithelial markers E-cadherin and upregulation of mesenchymal markers vimentin and N-cadherin (Figures 5G,I), suggesting that CXCL14 may promote the CRC progression through the regulation the EMT process. Here, CDH2 is linked to colorectal carcinoma.