In the present study, we demonstrated ROS treatment and CXCL14 overexpression could modulate the expression levels of cell cycle-related proteins (Cyclin A1/B1, CDK1/2) and EMT-related proteins (E-cadherin, N-cadherin, vimentin), suggesting that CXCL14 might be involved in ROS-induced cell cycle progression and EMT process, which was consistent with the role of ROS-induced CXCL14 in breast cancer reported by Pelicano et al. (2009b). This evidence concerns the gene CDH1 and breast cancer.