CTRP9 maintains a beneficial lipid profile and promotes plaque stability in addition to ameliorating endothelial dysfunction, mitigating inflammatory responses, inhibits the transformation of vascular smooth muscle cells into macrophage-like cells, and reducing foam cell formation (Liu et al., 2017; Sun et al., 2017; Zhang et al., 2018). This evidence concerns the gene C1QTNF9 and endothelial dysfunction.