Hyperexpression of CXCR4 on several peripheral blood leukocyte subsets was demonstrated in murine lupus models with active nephritis, namely (NZBxNZW)F1, B6.Sle1Yaa, BXSB, and MRL/lpr (Murphy Roths large/lymphoproliferation) mice (Balabanian et al., 2003; Wang et al., 2009; Cheng et al., 2018). Here, CXCR4 is linked to nephritis.