LIT-927 behaves as a “neutraligand” that interacts directly with the chemokine CXCL12 and could block it before it crosses the blood brain barrier known to be leaky in neuropsychiatric forms of lupus (Jeltsch-David and Muller, 2014; Nikolopoulos et al., 2019) or before it reaches its targets in the kidneys, for example. The gene discussed is CXCL12; the disease is systemic lupus erythematosus.