As it was claimed that the CXCR4 pathway is deregulated in lupus (Wang et al., 2009, 2010; Biajoux et al., 2012; Launay et al., 2013; Zhao et al., 2017; Barrera-Vargas et al., 2018; Cheng et al., 2018), we examined if LIT-927 might correct some of these abnormalities. Here, CXCR4 is linked to systemic lupus erythematosus.