Meanwhile, suppression of pro-inflammatory, pro-fibrogenic and angiogenic cytokines, such as vascular endothelial growth factor (VEGF) and transforming growth factor β (TGF-β) is referred as a potent therapeutic approach for DM and its complications (Joshi et al., 2019; Lu et al., 2019). The gene discussed is TGFB1; the disease is diabetes mellitus.