Because the prognosis of patients with high expression of TPD52L2 is worse than that of patients with low expression of TPD52L2, we speculated whether the expression of TPD52L2 is related to the mutations of some common cancer-promoting genes, so we further analyzed the gene mutations (such as TP53, MUC16, and TTN) in high and low TPD52L2 expression groups (Figures 9A,B). The gene discussed is TP53; the disease is cancer.