CCND1 and malignant colon neoplasm: No toxic effects were related to resveratrol or GE treatments. Patients treated with resveratrol/GE had no change in Wnt target gene expression in colon cancer. Resveratrol and GE seemed to have different effects on normal colonic mucosa, whereas inhibition of Wnt target gene expression was determined by microarray and confirmed by qRT-PCR of cyclinD1 and axinII. Resveratrol or GE may play a beneficial role in colon cancer prevention