TP53 and neoplasm: The combination of TriCurin polyphenols (curcumin, epicatechin 3-gallate, and resveratrol) reduces mRNA and the protein levels of E6 and E7, leading to the accumulation of p53 and pRb, thus decreasing tumor weight and cell proliferation by 86.3 and 19.9%, respectively (Piao et al., 2017).