In an investigation, it was shown that combining the grape polyphenol resveratrol, quercetin, and catechin at equimolar concentrations inhibits mTOR signaling by means of a dual mechanism of PI3K/Akt and AMPK regulation and potentiates breast cancer to anti-EGFR therapy with Gefitinib, suggesting that this mixture may have synergistic effects against cancer (Castillo-Pichardo and Dharmawardhane, 2012). This evidence concerns the gene AKT1 and breast cancer.