However, accessibility, economic importance, beneficial health effects, and the safety of polyphenols compared to synthetic drugs (Karimi et al., 2015) make them perfect candidates to explore possible therapeutic effects for preventing or treating different types of cancer due to the capacity of polyphenols to modulate multiple signaling pathways such as MAPK and PI3K/Akt and the key proteins involved in cancer development, such as p53 and RAS, rendering a promising expectation regarding these compounds. Here, TP53 is linked to cancer.