The role of JNK in cancer development is found in its multiple targets that are implicated in many cell-regulation mechanisms, such as STAT1/3, c-Jun, c-Myc, FOXO4, Bcl-2, ATF2, Smad2/3, PPARγ1, and RXRα (Dou et al., 2019). The gene discussed is MAPK8; the disease is cancer.