MTOR and central nervous system cancer: Miconazole suppresses the expression of HIF1α through post-transcriptional regulation in glioma and breast cancer-derived cell lines; this was attributed to the inhibition of mammalian target of rapamycin (mTOR) and regulation of protein synthesis via induction of the phosphorylation of eIF2α, a downstream target of mTOR (Park et al., 2014).