Nevertheless, using several other approaches for creating glucocorticoid deficiency, not interfering with adrenomedullary catecholamines, we obtained convincing results about gastroprotective role glucocorticoids released during activation of HPA axis (Filaretova et al., 1998; Filaretova et al., 2004; Filaretova et al., 2008; Filaretova, 2011; Filaretova, 2017; Filaretova and Bagaeva, 2016) and their participation in gastroprotective action of CRF (Filaretova et al., 2012). This evidence concerns the gene CRH and familial glucocorticoid deficiency.