Various mouse models of AD have been developed, most mimicking the overproduction of Aβ through transgene expression of mutated human APP (hAPP) combined or not with the amyloidogenic presenilin (PS1) or the pathologic tau (Mucke et al., 2000; Oddo et al., 2003; Gotz and Ittner, 2008). This evidence concerns the gene MAPT and Alzheimer disease.