SNCA and Parkinson disease: Super-resolution imaging of Lewy bodies (LBs) has highlighted the presence of various organelles surrounding a crowded core containing α-synuclein, lipids, and fragmented membranes (Shahmoradian et al., 2019), which has led to a lively debate about the role of α-synuclein fibrillisation in the formation of LBs in Parkinson’s disease (PD; Lashuel, 2020; Ericsson et al., 2021).