Using transgenic Hvcn1 knockout (Hvcn1–/–) mice in which the Hvcn1 gene is deleted, many studies have shown that loss of the proton channel HVCN1 exhibits neuroprotective effects in CNS injury models, such as stroke (Wu et al., 2012), traumatic brain injury (Ritzel et al., 2021), and spinal cord injury (Li et al., 2021). The gene discussed is HVCN1; the disease is brain injury.