Using transgenic Hvcn1 knockout (Hvcn1–/–) mice in which the Hvcn1 gene is deleted, many studies have shown that loss of the proton channel HVCN1 exhibits neuroprotective effects in CNS injury models, such as stroke (Wu et al., 2012), traumatic brain injury (Ritzel et al., 2021), and spinal cord injury (Li et al., 2021). This evidence concerns the gene HVCN1 and Stroke.