HVCN1 and Peripheral demyelination: We showed that among HVCN1+ microglia/macrophages, the proportion of iNOS+ microglia/macrophages were about 80%, whereas the proportion Arg1+ microglia/macrophages were about 15% (Figures 2C,D), indicating that within the focal demyelination lesion, the upregulated HVCN1 was mainly in iNOS+ microglia/macrophages.