PSEN1 and prion disease: These animal models include the transgenic mice co-expressing familial AD-linked mutations on the amyloid precursor protein (APP) and presenilin 1 (PS1) (Lazarov et al., 2005), 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 6-hydroxydopamine (6-OHDA) Parkinson’s disease model (Faherty et al., 2005; Jadavji et al., 2006), and the mice expressing the human SOD1(G93A) gene mutation, the most common model of amyotrophic lateral sclerosis (Stam et al., 2008) and in the mouse prion disease (Bento-Torres et al., 2017).