Proteins such as amyloid precursor protein (APP) vital in the pathological outcome of neurological disorders such as AD have been recently shown to be critically involved in the cholesterol turnover for neuronal activity, supporting the importance of cholesterol homeostasis in a wider context (Pierrot et al., 2013; Grimm et al., 2017; Cho et al., 2020). Here, APP is linked to Alzheimer disease.