SLC17A7 and Alzheimer disease: A role for glutamate in the pathology of AD is demonstrated since, similar to MS, glutamate clearance may be impaired through reduced expression of cortical glutamate transporters such as GLT-1 (Li et al., 1997; Scott et al., 2011; Hefendehl et al., 2016) and vesicular glutamate transporter 1 (VGLUT1) (Kirvell et al., 2006).