MAPT and early-onset autosomal dominant Alzheimer disease: Accumulation of tau in neurofibrillary tangles (NFTs) and fibrillar aggregates participates in dementia and behavioral dysfunctions in numerous neurodegenerative diseases which include Alzheimer’s disease (AD) and frontotemporal lobar degeneration which includes progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), Pick’s disease (PiD), and FTLD-tau (frontotemporal dementia with parkinsonism caused by MAPT; Ballatore et al., 2007; Wolfe, 2012; Goedert et al., 2017).