However, in tauopathies, tau loses its ability to bind to MTs through modifications of tau by phosphorylation (Alonso et al., 1994; Iqbal et al., 1994; Wang et al., 1995), proteolysis (Wang et al., 2007; Quinn et al., 2018), and other post-translational modifications (PTMs; Pevalova et al., 2006; Martin et al., 2011; Alquezar et al., 2020), as well as by tau mutations (Goedert and Spillantini, 2000, 2001; Spillantini and Goedert, 2000; Goedert, 2005; Goedert et al., 2017). Here, MAPT is linked to tauopathy.