It was found that phosphorylations at S202, T212, T231, S396, S404, and S422 were much higher in AD brain than in developing rat brain, whereas the phosphorylation levels of T181, S199, T205, S214, S262, S356, and S409 in AD brain were similar or lower than tau in the developing rat brain. The gene discussed is MAPT; the disease is Alzheimer disease.