Multivariable analysis of independent prognostic factors: anatomical site, histological type, tumor grade, LVI (absent versus present), TN staging, intra-tumoral inflammatory infiltrate (low versus high), expression of TSP50, SERCA2 and IL-8 proteins (low expression versus high) was conducted showing that TSP50, SERCA2 and IL-8 overexpression were significantly associated with adverse prognosis along with high tumor grade, LVI, advanced T stage, presence of regional lymph node invasion and high ITL Table 5. The gene discussed is ATP2A2; the disease is neoplasm.