The expression of TSP50 as a potential oncoprotein in association with SERCA2 and inflammatory cytokine (IL-8) in colorectal adenoma (CRA) and CRC and the relation of these biomarkers’ expression to intratumoral inflammatory infiltrate and other clinicopathological and prognostic factors in CRC have not been clarified. This evidence concerns the gene PRSS50 and colorectal adenoma.