Therefore, the aim of this study is to investigate the roles of TSP50 as an oncoprotein with altered calcium metabolism and inflammatory cytokine namely SERCA2 and IL-8 respectively in CRA and CRC, understanding their roles in CRC initiation and propagation and the relation of these biomarkers’ expression to the intratumoral inflammatory infiltrate and other clinicopathological and prognostic factors. This evidence concerns the gene PRSS50 and colorectal carcinoma.