These findings were similar to previous studies which showed that colorectal carcinoma with increased SERCA2 expression was significantly associated with serosal invasion, lymph node metastasis and advanced tumor stage compared to those with low SERCA2 expression meaning that SERCA2 may be a crucial biomarker in the development and progression of CRC [25, 33, 34]. Here, ATP2A2 is linked to colorectal carcinoma.