Thus the increased expression of IL-8 and SERCA2 in relation to high intratumoral inflammatory infiltrate with subsequent increase in TSP50 protein expression in CRC, in the present study, and the significant association of these biomarkers’ expression to adverse clinicopathological and prognostic factors namely: LVI and advanced TNM staging are of crucial value for understanding the role of these biomarkers in CRC initiation, growth and invasion. The gene discussed is PRSS50; the disease is colorectal carcinoma.