Besides, Bourdenx et al.206 demonstrated that poly(DL-lactide-co-glycolide) acidic nanoparticles (PLGA-aNPs) were internalized into lysosomes within 24 h after the treatment and restored defective lysosomal acidification and autophagy-lysosomal pathways in three different pathological PD models, including fibroblasts from PD patients with ATP13A2 mutations, fibroblasts from PD patients with glucocerebrosidase (GBA) mutations, and BE-M17 cells with ATP13A2 knockdown. The gene discussed is ATP13A2; the disease is Parkinson disease.