PDLIM7 and cancer: However, the changes mentioned above not only benefit cancer development but also lead to the reduced stability of lysosomal membranes and make lysosomes in cancer cells more susceptible to LMP, which may provide the therapeutic windows we seek.2,24,26,137 Considering the great role of these changes and dysfunctions in lysosomes in cancer cells, it is feasible to develop strategies targeting lysosomes to treat cancer (Fig. 4).