Thus, to explore the critical biological characteristics of IMP2-mediated m6A methylation stability and its associated ZFAS1 expression in CRC tumorigenesis and progression, we initially detected the expressions of IMP2 and ZFAS1 after interfering IMP2 expression in both HCT116 and SW620 CRC cells. The gene discussed is ZFAS1; the disease is colorectal carcinoma.