Interestingly, the decrease in OLA1 expression could not only reduce lactate accumulation in CRC cells but also reduce ATP content in cells; however, ZFAS1-WT, but not ZFAS1-Mut, could restore the effects of OLA1 deficiency (Fig. 5f, g, Additional file 2: Fig. S5b, c). This evidence concerns the gene OLA1 and colorectal carcinoma.