INSR and Insulin resistance: Traditional Chinese medicine has been widely used in the treatment of metabolic syndrome; our previous basic study confirmed that Bushen Huatan Decoction can activate the PI3K/AKT pathway [10] and increase the expression levels of insulin receptor (INSR) and IRS-1 protein in adipose tissue of IR-PCOS model rats, thus improving glucose and lipid metabolism and insulin resistance in rats.