Vulpinic acid elevated apoptotic cell death by increasing proapoptotic protein levels (FOXO-3, Bax), decreasing Bcl-2, pro-caspase-3 and pro-caspase-9 and altering the expression levels of specific tumor suppressor miRNAs (miR-1268a, miR-132-3p, miR-155-5p, miR-16–1-3p, miR-196b-5p, miR-197-3p, miR-2861, miR-3923, miR-423-5p, miR-4291, miR-6740-5p and miR-769-5p). Here, FOXO3 is linked to neoplasm.