Ethanolic propolis extract elevated apoptotic cell death by increasing proapoptotic protein levels (p21, Bax, p53, p53-Ser46 and p53-Ser15), decreasing mitochondrial membrane potential and altering the expression levels of specific tumor suppressors (miR-34, miR-15a and miR-16-5p) and oncogenic (miR-21) miRNAs. This evidence concerns the gene CDKN1A and neoplasm.