Protein or mRNA expression of GnRH and GnRHR was detected not only in pituitary cells but also in extra-pituitary cells; ovarian, breast, prostate tissues, and various cancer cell lines including breast (MCF-7 and MDA-MB-468) and prostate cancer (PCa) cells (PC-3 and LNCaP) [11–14]. This evidence concerns the gene GNRH1 and Familial prostate cancer.