We observed a significant enrichment in pathways related to angiogenesis (VEGF, platelet-derived growth factor, angiopoietin), which are currently therapeutically targeted to inhibit neovascularization in diabetic retinopathy, advanced age-related macular degeneration, and many cancers.9–11 A significant genetic correlation with skin color was also observed, and several of the fine-mapped top variants are strongly associated with skin neoplasms and lighter skin color (ie, at the PoPS-prioritized genes IRF4, SLC45A2, OCA2, DUSP22, ACTG1). The gene discussed is IRF4; the disease is diabetic retinopathy.