Notably, the missense variant rs5442-A in GNB3 variant has previously been associated with retinal microvascular diameter,90 hypertension,91 refractive error,92,93 and advanced age-related macular degeneration.94 Inflammatory and chemokine pathways were significantly enriched in both GWAS studies, with contributing genes prioritized by PoPS including IL2RA, IL23A, IL1R2, IL2, IL7R, IL6, MEF2A, PDGFRA, HLA markers, and others (Tables S16 and S17). Here, GNB3 is linked to age-related macular degeneration.