In particular, retinal density– and FD-lowering alleles at several PoPS-prioritized genes showed associations with higher risk of skin neoplasms, malignant melanoma, and eye cancer (IRF4/DUSP22, SLC45A2); a separate set of loci showed associations with lighter skin color (GNB2, ACTG1). This evidence concerns the gene IRF4 and skin neoplasm.