RET融合发生于0.7%-2%的非小细胞肺癌(non-small cell lung cancer, NSCLC),在腺癌组织学类型中检出率更高[11-15]。常见的融合伴侣包括KIF5B(约70%)、卷曲螺旋结构域蛋白6(coiled-coil domain-containing protein 6, CCDC6)(约20%),检出率低于2%的包括核受体共激活因子4(nuclear receptor coativator 4, NCOA4)、红细胞生成素肝细胞受体A(erythropoietin-producing hepatocyte receptor A, EPHA)以及磷脂酰肌醇结合网格蛋白组装蛋白(recombinant phosphatidylinositol binding clathrin assembly protein, PICALM)[16]。含三联基元33(tripartite motif-containing, TRIM33)也有报告[17]。. This evidence concerns the gene KIF5B and non-small cell lung carcinoma.