Previous studies had shown the evidence of ANKHD1 in the malignant phenotype of cancer cells, including promoting cancer cell proliferation, migration, invasion, and tumorigenesis [42], by positively regulating of YAP1 [43, 44], JAK/STAT [45], and STMN1 [46, 47], and negatively regulating p21 [48]. Here, CDKN1A is linked to cancer.