NEDD4L and cancer: NEDD4L expression is downregulated in multiple types of human cancers (https://portal.gdc.cancer.gov) (Fig. 4B), suggesting that NEDD4L expression levels are downregulated in human lung cancer tissues and correlate with poor prognosis in lung cancer, in turn suggesting that NEDD4L deficiency may promote cancer cell invasion during malignant progression (http://bioinfo.henu.edu.cn/LUCA/LUCAList.jsp) (Fig. 4C).