However, the tumours in sorafenib-injected mice implanted with Cdc25A + sh-ErbB2-transfected cells were smaller than those in sorafenib-injected mice bearing Cdc25A alone (sorafenib + Cdc25A) or Cdc25A + sh-NC (sorafenib + Cdc25A + sh-NC)-transfected cells) (Fig. 8A–C), showing that the knockdown of ErbB2 blocks the effects of Cdc25A. This evidence concerns the gene ERBB2 and neoplasm.