FANCD2 and neuroblastoma: In the present study, we revealed that ATRX depletion in TP53 wild-type (wt) NB cells was associated with an increased frequency of DSBs and a subsequent RS-induced DNA damage response (DDR), which was impaired by the loss of p53 through the activation of G4 DNA helicases or the FA DNA repair pathway protein, FANCD2.