In this study, BRAF V600E mutation was associated with aggressive disease in small papillary thyroid carcinoma ≤ 1.5 cm and papillary thyroid microcarcinoma ≤ 1 cm, defined by: ETE, LNM, and high-risk histological variants (tall cell, columnar, solid/trabecular, diffuse sclerosing). This evidence concerns the gene BRAF and thyroid gland papillary carcinoma.