Moreover, lipocalin 2 (LCN2) inhibits ferroptosis by limiting iron uptake [66–68], while aconitase 1 (ACO1, also known as IRP1) and iron responsive element binding protein 2 (IREB2, also known as IRP2) promote ferroptosis in cancer cells by regulating the translation of iron metabolism-related protein [69]. This evidence concerns the gene ACO1 and cancer.