NOS2 and neoplasm: N-3 docosapentaenoic acid, an unsaturated fatty acid in fish oil, specifically increases the expression of FAO-related genes (A-FABP, Cpt1b, PCX, and UCP2) and apoptosis-related genes (iNOS, RIPK3, caspase-8, and caspase-11), that induce ROS-mediated macrophage apoptosis and reduce pro-tumor activity.