Detailed results of these analyses are given in Table S3 and can be summarized by four main findings: First, in the DLPFC, mtDNAcn is mainly associated with tau (p = 2.9 × 10− 6, t test) rather than amyloid-β pathology (p = 0.011, t test) and is also associated with cognition proximate to death (p = 7.9 × 10− 10, t test) and cognitive decline (p = 1.8 × 10− 9, t test). Here, MAPT is linked to Mental deterioration.