Combination therapies that can exert multiple effects on disease biology (e.g. anti-amyloid and/or anti-TAU and/or anti-inflammatory agents) have been recently considered and are currently in the drug development pipeline as stand-alone or add-on treatments to those already in the clinic (cholinesterase inhibitors and NMDA receptor antagonists) for AD (for a systematic review of ongoing AD clinical trials, see [13, 19, 20]). Here, BCHE is linked to Alzheimer disease.