Intracerebral infusion of lentiviral constructs expressing miR-188-5p in 5xFAD mice restores dendritic spine density and memory deficits in contextual fear conditioning and T-maze tests [93], while restoring miR-132 levels through direct delivery of miR-132 synthetic mimics into the brain of different AD mouse models (APP/PS1, 3xTg AD and APPNL-G-F mice), ameliorates Aβ40-42 levels, Tau phosphorylation, deficits in adult hippocampal neurogenesis and cognition [33, 64, 67]. This evidence concerns the gene APP and Alzheimer disease.