NFKB1 and rheumatoid arthritis: Here, we investigated the effect of EF on the: (i) proliferation, migration, and apoptosis of human fibroblast-like synoviocytes in rheumatoid arthritis (HFLS-RA); (ii) osteoclast differentiation in RAW264.7 cells; (iii) bone destruction via the NF-κB pathway in a rat model of CIA.