The combination of PD-L1+ tumour cells and intense reaction (R3+) of PD-L1+ non-neoplastic cells (high PD-L1+ group) was found in eight large cell PTCL-TFH patients (62%), which was significantly higher than in F-TCL (0%) (p = 0.036; Fig. 2d). This evidence concerns the gene CD274 and mature T-cell and NK-cell non-Hodgkin lymphoma.