Interestingly, COX-2 inhibition with a concomitant attenuation of PGE2/EP2 in rat cortexes is accompanied by significant inhibition of glutamate release and avoidance of glutamate excitotoxicity which have been implicated in epilepsy as co-morbidity in individuals with autism [62, 63]. The gene discussed is PTGS2; the disease is epilepsy.