Among them, focal implications of several oncogenes like c-Met proto-oncogene (MET) and telomerase reverse transcriptase (TERT), as well as the genetic deletions of tumor suppressor genes including TP53 (Tumor Protein P53) and PTEN (phosphatase and tensin homolog) were characterized as essential molecular events underlying HCC development and progression [8, 10–12]. Here, TP53 is linked to hepatocellular carcinoma.