NFKB1 and hepatocellular carcinoma: Here in this study, we also showed that the expression of p65 protein, one major subunit of the NF-kB protein, was remarkably decreased in both the HepG2 and Huh-7 cells, indicating the involvement of NF-kB signaling and its interaction with the COMPASS complex during MKL1-regulated HCC pathogenesis.