BAG3 and neoplasm: Moreover, it has been shown that BAG3 secreted by pancreatic tumor cells induces the activation of Tumor‐Associated Macrophages (TAMs) through the binding to its receptor Interferon‐induced transmembrane protein (IFITM)‐2, which in turn activates p38 and PI3K and stimulates the production of molecules, such as interleukin (IL)‐6, that support the neoplastic growth.