Classically, p85α and p85β are considered to be similar proteins associated with activated receptor tyrosine kinases (RTK) that induce PI3K activation; however, PIK3R1/p85α is the most abundant subtype in tumour‐free tissues, but its expression is reduced in cancer, which has a tumour‐suppressor function.30 This evidence concerns the gene NTRK1 and neoplasm.